ANR "PERSIST"

ANR 2010 JCJC 0303 01 "PERSIST" (2010-2014)

"Multidimensional Characterization of the ECG Signal for Predicting the Success of the RF Catheter Ablation Therapy in Persistent Atrial Fibrillation Patients"

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Project Summary

Held responsible of up to 25% of strokes, atrial fibrillation (AF) is the most common sustained cardiac arrhythmia encountered in clinical practice. The radiofrequency catheter ablation therapy is increasingly employed to treat this cardiac condition, but it is a costly, time-consuming procedure with risks of complications for the patient and uncertain success rates. To improve the patient-tailored management of persistent AF, the project aims at an accurate automated prediction of catheter ablation outcome by means of signal processing techniques for exploiting the spatial diversity (multiple electrodes) of surface ECG recordings.

Keywords

Atrial fibrillation, catheter ablation, independent component analysis, matrix decompositions, principal component analysis, source separation, spatial diversity.

Funding

French National Research Agency (ANR)
Additional sources of support:
- French Ministry of Higher Education and Research (MESR)
- Centre Scientifique de Monaco (CSM)
- DreamIT Foundation
- Pôle de compétitivité EuroBioMed.

Project Participants

Computer Science, Signals and Systems Laboratory of Sophia Antipolis (I3S): M. Garibaldi, M. Meo, O. Meste, H, Rix, V. Zarzoso (project coordinator).
Cardiology Department, Monaco Princess Grace Hospital (CHPG): D. G. Latcu, I. Popescu, N. Saoudi (head of the Cardiology Department).

Publications

Book chapter "Noninvasive Cardiac Signal Analysis Using Data Decomposition Techniques", in: F. Cazals and P. Kornprobst (Eds.), Modeling in Computational Biology and Biomedicine: A Multidisciplinary Endeavor, Berlin, Heidelberg: Springer Verlag, Chap. 3 pp. 83-116, 2013.
Journal articles "Catheter Ablation Outcome Prediction in Persistent Atrial Fibrillation Using Weighted Principal Component Analysis", Biomedical Signal Processing & Control (Special Issue on Atrial Arrhythmias), Vol. 8, No. 6, November 2013, pp. 958-968. "Spatial Variability of the 12-Lead Surface ECG as a Tool for Noninvasive Prediction of Catheter Ablation Outcome in Persistent Atrial Fibrillation", IEEE Transactions on Biomedical Engineering, Vol. 60, No. 1, January 2013, pp. 20-27. "Independent Component Analysis Using First-Order Statistics", Signal Processing, Special Issue on Latent Variable Analysis and Signal Separation, Vol. 92, No. 8, August 2012, pp. 1779-1784.
Conference papers

"Low-Rank Signal Approximations with Reduced Error Dispersion", in: Proc. EUSIPCO-2013, XXI European Signal Processing Conference, Marrakech, Morocco, September 9-13, 2013.
"Noninvasive Prediction of Catheter Ablation Acute Outcome in Persistent Atrial Fibrillation Based on Logistic Regression of ECG Fibrillatory Wave Amplitude and Spatio-temporal Variability", in: Proc. EMBC-2013, 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Osaka, Japan, July 3-7, 2013, pp. 5821-5824.
"Exploiting Intracardiac and Surface Recording Modalities for Atrial Signal Extraction in Atrial Fibrillation", in: Proc. EMBC-2013, 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Osaka, Japan, July 3-7, 2013, pp. 6015-6018.
"Multidimensional Characterization of Fibrillatory Wave Amplitude on Surface ECG to Describe Catheter Ablation Impact on Persistent Atrial Fibrillation", in: Proc. EMBC-2012, 34th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, San Diego, CA, USA, August 28 - September 1, 2012, pp. 617-620.
"Automatic Multilead Characterization of F-wave Amplitude Enhances Prediction of Catheter Ablation Outcome in Persistent Atrial Fibrillation", abstract in: Proc. European Heart Rhythm Association EUROPACE Congress, Athens, Greece, June 23-26, 2013.
"Predicting Catheter Ablation Outcome in Persistent Atrial Fibrillation Using Atrial Dominant Frequency and Related Spectral Features", in: Proc. EMBC-2012, 34th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, San Diego, CA, USA, August 28 - September 1, 2012, pp. 613-616.
"Mathematical Analysis of Atrial Spatiotemporal Complexity on Standard ECG for Catheter Ablation Outcome Prediction in Persistent Atrial Fibrillation", abstract in: Proc. European Society of Cardiology Congress 2012, Munich, Germany, August 25-29, 2012.
"Persistent Atrial Fibrillation Dominant Frequency on Standard ECG Predicts Catheter Ablation Outcome", abstract in: Proc. Cardiostim-2012, 18th World Congress on Cardiac Electrohysiology & Cardiac Techniques, Nice, June 13-16, 2012.
"ECG Spatiotemporal Complexity Predicts Catheter Ablation Outcome of Persistent Afib", abstract in: Proc. Cardiostim-2012, 18th World Congress on Cardiac Electrohysiology & Cardiac Techniques, Nice, June 13-16, 2012.
"Algorithms for Atrial Signal Extraction in Atrial Fibrillation ECGs: A Comparison Based on the Correlation Between Endocardial and Surface Dominant Frequency", in: Proc. 7th International Workshop on Biosignal Interpretation, Como, Italy, July 2-4, 2012.
(Le poster présenté dans le workshop a décroché le 3ème prix.)
"Nonnegative Matrix Factorization for Noninvasive Prediction of Catheter Ablation Outcome in Persistent Atrial Fibrillation", in: Proc. ICASSP-2012, IEEE International Conference on Acoustics, Speech and Signal Processing, Kyoto, Japan, March 25-30, 2012, pp. 601-604.
"Catheter Ablation Outcome Prediction in Persistent Atrial Fibrillation Based on Spatio-Temporal Complexity Measures of the Surface ECG", in: Proc. Computing in Cardiology, vol. 38, Hangzhou, China, Sept. 18-21, 2011, pp. 261-264.
"Non-invasive Prediction of Catheter Ablation Outcome in Persistent Atrial Fibrillation by Exploiting the Spatial Diversity of Surface ECG", in: Proc. 33rd Annual International IEEE Engineering in Medicine and Biology Society Conference (EMBC), Boston, MA, Aug. 30 - Sep. 3, 2011, pp. 5531-5534. <Réunion 26 mai 2011> <Réunion 15 nov 2011>

Last update: Dec. 23, 2013.